abstract：:The unfolded protein response (UPR) is a signaling pathway from the endoplasmic reticulum (ER) to the nucleus that protects cells from stress caused by misfolded or unfolded proteins. As such, ER stress is an ongoing challenge for all cells, given the central biologic importance of secretion as part of normal physiolo...

journal_title：Journal of dermatological science

authors： Sugiura K

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Skin derived precursors (SKP) comprise a subset of specialized dermal cells that can be distinguished from fibroblast by their capacity for spheroidal growth. Recent investigations have shown that hair follicles constitute a niche for this cell type, but their localization and their definite function in non-...

journal_title：Journal of dermatological science

authors： Ruetze M,Knauer T,Gallinat S,Wenck H,Achterberg V,Maerz A,Deppert W,Knott A

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Propionibacterium acnes (P. acnes), a gram-positive anaerobic bacterium, plays a critical role in the development of inflammatory lesion as a result of cytokines production by keratinocytes and macrophages activation. However, effect of P. acnes on iNOS/NO and COX-2/PGE2 production in macrophages is still un...

journal_title：Journal of dermatological science

authors： Tsai HH,Lee WR,Wang PH,Cheng KT,Chen YC,Shen SC

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:The molecular pathogenesis underlying recurrent exacerbations of atopic dermatitis (AD) is unclear. Some peripheral CCR4(+) and CCR7(+) helper memory T cells express the specific homing receptor, sialyl 6-sulfo Lewis X (G152 glycan). This glycan loses receptor activity via cyclization of its sialic acid moie...

journal_title：Journal of dermatological science

authors： Sakuma K,Furuhashi T,Kondo S,Yabe U,Ohmori K,Ito H,Aoki M,Morita A,Kannagi R

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Pachydermoperiostosis (PDP) is a rare genetic disorder characterized by 3 major symptoms: pachydermia including cutis verticis gyrata (CVG), periostosis, and finger clubbing. Recently, a homozygous mutation in the gene HPGD, which encodes 15-hydroxyprostaglandin dehydrogenase (15-PGDH), was found to be assoc...

journal_title：Journal of dermatological science

authors： Sasaki T,Niizeki H,Shimizu A,Shiohama A,Hirakiyama A,Okuyama T,Seki A,Kabashima K,Otsuka A,Ishiko A,Tanese K,Miyakawa S,Sakabe J,Kuwahara M,Amagai M,Okano H,Suematsu M,Kudoh J

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Mechanical transduction contributes to appropriate cell functions. Clinically, keloid, an uncontrolled fibrous overgrowth and scarring, preferentially affects skin areas subject to higher mechanical tension than others. Keloid-derived fibroblasts have exaggerated TGF-beta1-mediated responses, including smoot...

journal_title：Journal of dermatological science

authors： Lee CH,Hong CH,Chen YT,Chen YC,Shen MR

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Melaleuca alternifolia (tea tree) oil (TTO) applied topically in a dilute (10%) dimethyl sulphoxide (DMSO) formulation exerts a rapid anti-cancer effect after a short treatment protocol. Tumour clearance is associated with skin irritation mediated by neutrophils which quickly and completely resolves upon tre...

journal_title：Journal of dermatological science

authors： Ireland DJ,Greay SJ,Hooper CM,Kissick HT,Filion P,Riley TV,Beilharz MW

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Kojic acid is a fungal metabolite widely used in medicinal and cosmetic formulations as a skin-lightening agent based on its de-pigmenting activity. Although in human clinical studies kojic acid has been shown to be effective in the treatment of hyper-pigmentation disorders such as melasma, the reasons for i...

journal_title：Journal of dermatological science

authors： Choi H,Kim K,Han J,Choi H,Jin SH,Lee EK,Shin DW,Lee TR,Lee AY,Noh M

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Dry skin causes pruritus and discomfort in patients with xerosis and atopic dermatitis. General treatment for skin dryness involves the topical application of an emollient. However, more effective, simpler therapies are desired. Collagen tripeptide (CTP) is a highly purified, non-antigenic, low-allergenic co...

journal_title：Journal of dermatological science

authors： Okawa T,Yamaguchi Y,Takada S,Sakai Y,Numata N,Nakamura F,Nagashima Y,Ikezawa Z,Aihara M

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Ultraviolet (UV) A irradiation causes the degeneration of extracellular matrix in the skin dermis, mainly due to disrupted collagen homeostasis, resulting in the photo-aging of human skin. All-trans retinoic acid (ATRA) improves photo-aged human skin in vivo. OBJECTIVES:Although the effects of ATRA on colla...

journal_title：Journal of dermatological science

authors： Shim JH,Shin DW,Lee TR,Kang HH,Jin SH,Noh M

更新日期：2012-04-01 00:00:00

abstract：:Stem cells are fascinating because of their potential in regenerative medicine. Stem cell homeostasis has been thought to be mainly regulated by signals from their adjacent micro-environment named the "stem cell niche". However, recent studies reveal that there can be multiple layers of environmental controls. Here we...

journal_title：Journal of dermatological science

authors： Chen CC,Chuong CM

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Foot ulcers are one of the main diabetes complications due to its high frequency and difficulty of complete healing. There are several factors that participate in diabetic ulcers development and limited information exists about the role of antimicrobial peptides (AMP) in its pathogenesis. OBJECTIVE:The aim ...

journal_title：Journal of dermatological science

authors： Rivas-Santiago B,Trujillo V,Montoya A,Gonzalez-Curiel I,Castañeda-Delgado J,Cardenas A,Rincon K,Hernandez ML,Hernández-Pando R

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Glycolic acid (GA) has been widely used in cosmetic agents and superficial chemical peeling in recent years. It has long been concerned that UV irradiation would enhance the photosensitivity of GA on human skin. Therefore, it is mandatory to explore the biologic effects of concomitant exposure of GA and UV i...

journal_title：Journal of dermatological science

authors： Lai WW,Hsiao YP,Chung JG,Wei YH,Cheng YW,Yang JH

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:We recently reported use of photodynamic therapy (PDT) for treating keloid disease (KD). However, in view of high recurrence rates post any treatment modality, adjuvant therapies should be considered. Additionally, we previously demonstrated the effect of a novel electrical waveform, the degenerate wave (DW)...

journal_title：Journal of dermatological science

authors： Sebastian A,Allan E,Allan D,Colthurst J,Bayat A

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:Aberrant expression of microRNAs (miRNAs) has been implicated in oncogenesis of various tumors and primary cutaneous T cell lymphomas. Dicer, a ribonuclease III-like enzyme is essential for miRNA processing. OBJECTIVE:We initiated a retrospective study to characterize the alterations in the expression profi...

journal_title：Journal of dermatological science

authors： Valencak J,Schmid K,Trautinger F,Wallnöfer W,Muellauer L,Soleiman A,Knobler R,Haitel A,Pehamberger H,Raderer M

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND:UV radiation is the major environmental factor related to development of cutaneous melanoma. Besides sun exposure and the influence of latitude, some host characteristics such as skin phototype and hair and eye color are also risk factors for melanoma. Polymorphisms in DNA repair genes could be good candidat...

journal_title：Journal of dermatological science

authors： Gonçalves FT,Francisco G,de Souza SP,Luiz OC,Festa-Neto C,Sanches JA,Chammas R,Gattas GJ,Eluf-Neto J

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:High doses of sun-emitted UV-radiation induce reactive oxygen species (ROS) as major pro-oxidants thus inducing premature skin aging. The best prevention of the destructive action of free radicals in human skin is textile coverings, topical sunscreens and the development of a high antioxidative protective ne...

journal_title：Journal of dermatological science

authors： Darvin ME,Fluhr JW,Schanzer S,Richter H,Patzelt A,Meinke MC,Zastrow L,Golz K,Doucet O,Sterry W,Lademann J

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Ustekinumab has been evaluated in Caucasian patients with psoriasis, but no studies have been conducted in Asian patients. OBJECTIVE:To assess the efficacy and safety of ustekinumab in Taiwanese and Korean patients with moderate-to-severe psoriasis. METHODS:In this 36-week, multicenter, double-blind, place...

journal_title：Journal of dermatological science

authors： Tsai TF,Ho JC,Song M,Szapary P,Guzzo C,Shen YK,Li S,Kim KJ,Kim TY,Choi JH,Youn JI,PEARL Investigators.

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Netherton syndrome (NS, MIM 256500) is a potential live threatening autosomal-recessive skin disorder clinically characterized by the trias of congenital erythroderma, hair shaft anomalies and atopic diathesis. It is caused by mutations in the gene SPINK5 resulting in a deficiency of its processed protein na...

journal_title：Journal of dermatological science

authors： Roedl D,Oji V,Buters JT,Behrendt H,Braun-Falco M

更新日期：2011-03-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) plays important roles not only in the morphogenesis but also in wound repair, tissue fibrosis and cancer progression. Recently, regulatory mechanism of this process has been elaborately elucidated. EMT can be a new therapeutic target for treating skin ulcer, fibrosing alopecia, ...

journal_title：Journal of dermatological science

authors： Nakamura M,Tokura Y

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Repeated exposure to ultraviolet (UV) rays damages skin connective tissue, which is thought to be associated with wrinkle formation. We hypothesized that repeated mild inflammation may cause the connective tissue alterations in photoaging. OBJECTIVE:To clarify the behavior of neutrophils and neutrophil elas...

journal_title：Journal of dermatological science

authors： Takeuchi H,Gomi T,Shishido M,Watanabe H,Suenobu N

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that large (>1 cm) diameter circular cutaneous wounds induce follicular neogenesis in mice. However, the effects of non-circular wounds or smaller circular wounds on the hair follicle cycle remain poorly understood. OBJECTIVE:We investigated whether non-circular wounds or smaller (≤1 ...

journal_title：Journal of dermatological science

authors： Jiang S,Zhao L,Teklemariam T,Hantash BM

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Chemical peeling is one of the dermatological treatments available for certain cutaneous diseases and conditions or improvement of cosmetic appearance of photoaged skin. OBJECTIVES:We assessed the photochemopreventive effect of several clinically used chemical peeling agents on the ultraviolet (UV)-irradiat...

journal_title：Journal of dermatological science

authors： Abdel-Daim M,Funasaka Y,Kamo T,Ooe M,Matsunaka H,Yanagita E,Itoh T,Nishigori C

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:Granzyme B (GrB) is recognized to induce apoptosis; however, little is known about its possible role in other biological events. IL-18, a potent inflammatory cytokine, is produced as an inactive precursor (proIL-18). Several cells, including monocytes/macrophage lineage and non-hematopoietic cells such as ke...

journal_title：Journal of dermatological science

authors： Omoto Y,Yamanaka K,Tokime K,Kitano S,Kakeda M,Akeda T,Kurokawa I,Gabazza EC,Tsutsui H,Katayama N,Yamanishi K,Nakanishi K,Mizutani H

更新日期：2010-08-01 00:00:00

abstract：:Angiogenesis is defined as the formation of new capillaries from pre-existing blood vessels. The process of angiogenesis is tightly regulated by a balance between pro- and anti-angiogenic factors. Vascular endothelial growth factor (VEGF) is a pro-angiogenic factor and several anti-VEGF therapies are used in the treat...

journal_title：Journal of dermatological science

authors： Canavese M,Altruda F,Ruzicka T,Schauber J

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Glycolic acid (GA) is the most commonly used alpha-hydroxy acid (AHA) for dermatologic applications, and is considered as a versatile superficial peeling agent for facial rejuvenation. Its therapeutic effect includes acceleration of epidermal turnover without apparent inflammation, and its action is pH-depen...

journal_title：Journal of dermatological science

authors： Denda S,Denda M,Inoue K,Hibino T

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Lichen planopilaris (LPP) and pseudopelade of Brocq (PPB) are two scarring alopecia diagnoses that exhibit similar clinical features. Some suggest LPP and PPB are not distinct diseases, but rather different clinical presentations in a spectrum derived from the same underlying pathogenic mechanism. OBJECTIVE...

journal_title：Journal of dermatological science

authors： Yu M,Bell RH,Ross EK,Lo BK,Isaac-Renton M,Martinka M,Haegert A,Shapiro J,McElwee KJ

更新日期：2010-01-01 00:00:00

abstract：BACKGROUND:Evidence suggests anti-inflammatory effects of glucosamine (GS) on inflammatory diseases. COX-2 is an enzyme to produce prostaglandins. MMPs are the family of matrix metalloproteinases degradable of ECM. Excess expression of COX-2 or MMPs involves in skin inflammation. OBJECTIVE:We evaluated whether GS-HCl ...

journal_title：Journal of dermatological science

authors： Hong H,Park YK,Choi MS,Ryu NH,Song DK,Suh SI,Nam KY,Park GY,Jang BC

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Canine atopic dermatitis (cAD) is a common condition in dogs that may be a naturally occurring model for human atopic dermatitis (hAD). Despite this, comparative research is limited, particularly into the genetic background of cAD. OBJECTIVES:1. Measure candidate gene expression in cAD skin using quantitati...

journal_title：Journal of dermatological science

authors： Wood SH,Clements DN,Ollier WE,Nuttall T,McEwan NA,Carter SD

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Th17 is a newly identified effector T cell lineage which plays a central role in many human inflammatory diseases and experimental animal models. Epicutaneous sensitization with a protein antigen has been proven to induce a Th2-predominant immune response and lead to development of atopic diseases in a murin...

journal_title：Journal of dermatological science

authors： Wang LF,Chiu HC,Hsu CJ,Liu CY,Hsueh YH,Miaw SC

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE) is an autosomal recessive metabolic disorder with ectopic mineralization in the skin, eyes and cardiovascular system. PXE is caused by mutations in ABCC6. OBJECTIVE:To examine 54 unrelated South African PXE patients for ABCC6 PXE causing mutations. METHODS:Patients were scree...

journal_title：Journal of dermatological science

authors： Ramsay M,Greenberg T,Lombard Z,Labrum R,Lubbe S,Aron S,Marais AS,Terry S,Bercovitch L,Viljoen D

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Skin lesions commonly affect AIDS patients. The pathogenesis of certain dermatologic disorders primarily associated to HIV-1 is unclear, and better forms of therapy for these conditions need to be discovered. Transgenic animal models represent a novel approach for the study of these disorders and for the que...

journal_title：Journal of dermatological science

authors： Cedeno-Laurent F,Bryant J,Fishelevich R,Jones OD,Deng A,Eng ML,Gaspari AA,Trujillo JR

更新日期：2009-02-01 00:00:00

abstract：:Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are considered part of a spectrum of adverse cutaneous drug reactions showing severe and extensive skin detachment. TEN and SJS are morphologically characterized by active apoptotic keratinocyte cell death that results in the separation of the epiderm...

journal_title：Journal of dermatological science

authors： Abe R

更新日期：2008-12-01 00:00:00

abstract：:Genetically engineered mouse models are invaluable to investigators in nearly all areas of biomedical research. The use of genetically engineered mice has allowed researchers to explore fundamental functions of genes in a mammal that shares substantial similarities with human physiology and pathology. Genetically engi...

journal_title：Journal of dermatological science

authors： Chen J,Roop DR

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Main pathway in human melanocytes through which signal from the melanocortin system reaches the melanogenesis enzymes is cAMP/PKA pathway and it is modulated by Wnt and MAPK pathways. In our previous study we established significant increase of melanocortin receptor expression in unaffected skin of vitiligo ...

journal_title：Journal of dermatological science

authors： Kingo K,Aunin E,Karelson M,Rätsep R,Silm H,Vasar E,Kõks S

更新日期：2008-10-01 00:00:00

abstract：:Contact dermatitis is an integral part of dermatology. Many patients affected by contact dermatitis suffer significant morbidity and require prompt diagnosis and treatment. Here we give an overview of contact dermatitis related presentations made during the British Contact Dermatitis Society at 87th annual meeting of ...

journal_title：Journal of dermatological science

authors： Alexandroff AB,Gawkrodger DJ

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:1 alpha,25-Dihydroxyvitamin D3 (1 alpha,25(OH)2D3), the active form of vitamin D, suppresses keratinocyte proliferation, promotes keratinocyte differentiation, and induces involucrin expression. Peroxisome proliferation-activated receptors (PPARs) are ligand-activated transcription factors. It has been repor...

journal_title：Journal of dermatological science

authors： Dai X,Sayama K,Shirakata Y,Tokumaru S,Yang L,Tohyama M,Hirakawa S,Hanakawa Y,Hashimoto K

更新日期：2008-04-01 00:00:00

abstract：BACKGROUND:The tetracycline (Tet) responsive system is a valuable tool that is routinely used in a wide variety of mammalian cells for regulatable expression of gene products. However, technical difficulties such as harsh selection conditions and extensive screening processes to identify suitably responsive clones limi...

journal_title：Journal of dermatological science

authors： Nagarajan P,Sinha S

更新日期：2008-01-01 00:00:00

abstract：:Smoking tobacco is the most preventable cause of morbidity and is responsible for more than three million deaths a year worldwide. In addition to a strong association with a number of systemic diseases, smoking is also associated with many dermatological conditions, including poor wound healing, premature skin aging, ...

journal_title：Journal of dermatological science

authors： Morita A

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Decreased skin elasticity is considered as a factor that promotes wrinkle formation. However, the relationship between decreased skin elasticity and the formation of wrinkles is not fully understood. OBJECTIVE:The purpose of this study is to characterize the relationship between skin elasticity and wrinkle ...

journal_title：Journal of dermatological science

authors： Fujimura T,Haketa K,Hotta M,Kitahara T

更新日期：2007-09-01 00:00:00